PE-22-28
Research-Grade Peptide · 99%+ Purity · COA Certified
Volume Discounts
Product Description
Synthetic Peptide for Neuropharmacology Research
Technical Overview
PE-22-28 10mg is a synthetic peptide compound developed for laboratory research involving two-pore-domain potassium channel modulation, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying TREK-1 channel function, synaptic plasticity and mood-circuit signaling, and related biochemical mechanisms.
PE-22-28 is a heptapeptide fragment corresponding to the C-terminal 22-28 region of spadin, the propeptide released during sortilin maturation. It selectively inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel, modulating neuronal excitability in preparations from cortex, hippocampus, and dorsal raphe.
Researchers employ PE-22-28 to probe TREK-1 contributions to fast-onset antidepressant signaling, neurogenesis, and serotonergic activity in rodent brain-slice and primary-culture models. Its relative ease of synthesis compared to full-length spadin makes it the preferred tool compound for TREK-1 antagonism studies.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: PE-22-28
Strength: 10mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Product Specifications
| CAS Number | 1234388-01-0 |
|---|---|
| Molecular Formula | C35H55N11O9 |
| Molecular Weight (g/mol) | 773.89 |
| Amino Acid Count | 7 |
| Amino Acid Sequence | Heptapeptide Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) corresponding to the C-terminal 22-28 region of spadin; linear, unmodified termini (full sequence per COA). |
| Purity | �?�99% by HPLC �� COA available |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations. |
| Storage Conditions | Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol. |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not for human or animal consumption.
Research Workflow Steps
Store Properly
Refrigerate reconstituted solution at 2–8°C. Use within 30 days.
Document Research
Log batch number, concentration, and research notes per lab protocol.
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
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About This Product
Is this peptide research grade?
Yes. All our peptides are 99%+ purity research grade, verified by independent 3rd-party labs with full Certificates of Analysis.
What does "Research Use Only" mean?
Our peptides are intended exclusively for laboratory research and educational purposes. They are not manufactured for human consumption, diagnostic use, or therapeutic application.
How do I store this product?
Unreconstituted: store at -20°C for long-term storage or room temperature for up to 30 days. Reconstituted: refrigerate at 2-8°C and use within 30 days.
How fast will my order ship?
Orders placed before 2PM EST ship same-day via tracked shipping. Most USA orders arrive within 2-3 business days.
Can I see the COA before buying?
Yes. Every batch COA is available on our COA page before purchase — not after.
What if I'm not satisfied?
We stand behind our quality. If the product doesn't meet specifications, contact us within 7 days of delivery and we'll make it right.
