AP-SEM-1™
Catalog reference NN9535 · CAS 910463-68-2
Third-Party Tested · COA AvailableNN9535 20 mg is a synthetic peptide used in laboratory research for incretin signaling and GLP-1 receptor interaction studies. HPLC-purified for high analytical purity, it is suitable for investigating peptide-receptor activity and biochemical mechanisms.
- 99.9% Purity
- Research Grade
- COA Verified
- Third-Party Tested
5 mg is temporarily out of stock. Try another strength above — or get an email the moment it's back:
- Certificate of Analysis available for every lot
- ≥99% purity, HPLC & mass-spec verified
- Ships from a U.S. facility — same-day before 12pm CT
- Secure checkout · Free shipping on orders $300+
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AP-SEM-1™In your orderSynthetic Peptide for Incretin Pathway Research
Technical Overview
NN9535 is a synthetic peptide compound developed for laboratory research involving incretin signaling and GLP-1 receptor pharmacology, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying receptor-agonist binding profiles, downstream cAMP and insulinotropic signaling responses, and related biochemical mechanisms.
NN9535 is a long-acting GLP-1 receptor analog featuring an Aib substitution at position 2 to confer DPP-IV resistance and a fatty-acid (C18 diacid) side chain at Lys26 that promotes albumin binding for extended plasma residence. In research models, it is investigated as a tool compound for probing GLP-1R conformational dynamics and beta-arrestin recruitment.
Investigators commonly use this analog to dissect incretin-axis signaling in pancreatic islet preparations, hypothalamic appetite-regulation studies, and gastric motility models. Comparative work alongside native GLP-1 and LY3298176 enables receptor-selectivity and biased-agonism characterization.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: NN9535
Available Strengths: 5 mg · 10 mg · 20 mg · 30 mg · 50 mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Certificate of Analysis & Safety Data
Frequently Asked Questions
Is AP-SEM-1™ third-party tested?
Yes. Every lot is independently third-party tested for identity and purity — ≥99% by HPLC and mass spectrometry — with a lot-matched Certificate of Analysis available to download on this page.
Can I see the Certificate of Analysis before buying?
Yes. A lot-matched COA is available on this product page and in our COA library before purchase, documenting identity, purity, and full analytical results.
What does 'Research Use Only' mean?
This product is supplied strictly for laboratory and research use only (RUO). It is not a drug, food, supplement, or cosmetic, is not approved by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease, or for human or veterinary consumption.
How is it shipped and stored?
Orders placed before 12pm CT typically ship the same business day from our U.S. facility with tracking. Store the lyophilized material at −20°C, protected from light and moisture.
